Anaerobic protoporphyrin biosynthesis does not require incorporation of methyl groups from methionine
نویسندگان
چکیده
منابع مشابه
Incorporation of L-methionine-methyl-14C into gentamicins.
Gentamicin C complex, produced by Micromonospora purpurea1*2), is composed of three components, Cla, C2 and Q (Fig. 1). These components are methylaminoglycosides, which are distinct from other related antibiotics such as the kanamycins, neomycinsand paromomycins. As seen in Fig. 1, gentamicins Cla, C2, and Q possess one C-methyl and one N-methyl group, two C-methyl and one N-methyl groups and ...
متن کاملDoes triacylglycerol biosynthesis require diacylglycerol acyltransferase (DAGAT)?
Microsomal membrane preparations from the developing seeds of sunflower (Helianthus annuus L.) catalyse the conversion of sn-glycerol-3-phosphate and acyl-CoA to triacylglycerol via phosphatidic acid and diacylglycerol. The formation of diacylglycerol from phosphatidic acid was Mg2+ dependent and in the presence of EDTA phosphatidic acid accumulated. This property was used to generate large qua...
متن کاملNoncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin.
It has been generally accepted that biosynthesis of protoheme (heme) uses a common set of core metabolic intermediates that includes protoporphyrin. Herein, we show that the Actinobacteria and Firmicutes (high-GC and low-GC Gram-positive bacteria) are unable to synthesize protoporphyrin. Instead, they oxidize coproporphyrinogen to coproporphyrin, insert ferrous iron to make Fe-coproporphyrin (c...
متن کاملIncorporation of influenza A virus genome segments does not absolutely require wild-type sequences.
The efficient incorporation of influenza virus genome segments into virions is mediated by cis-acting regions at both ends of the viral RNAs. It was shown previously that nt 16-26 at the 3' end of the non-structural (NS) viral RNA of influenza A virus are important for efficient virion incorporation and that nt 27-56 also contribute to this process. To understand further the signalling requirem...
متن کاملIncorporation of L-methionine-methyl-14C into gentamicins. II. Large-scale preparation of methyl-14C-gentamicins.
Methyl-14C-gentamicins were prepared from incubation of Micromonospora purpurea in the presence of added methyl-'4C-L-methionine, and products with high specific radioactivity were isolated in satisfactory yields. In the previous paper1), we have shown in shake flask fermentation a high and selective incorporation of radioactivity from methyl-14C-L-methionine into gentamicins. Consequently, we ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1995
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.177.20.5778-5783.1995